The root of Asparagus racemosus of Lilliaceae family is traditionally used in the treatment of several diseases. The aim of the present study was to evaluate the ethanolic root extract of the Asparagus racemosus for hepatoprotective effect against carbontetrachloride-induced liver damage in rats. Administration of ethanolic root extract of Asparagus racemosus protect the liver from toxic effects of carbon tetrachloride by reducing the elevated levels of Serum glutamate pyruvate transaminase (SGPT), Serum glutamate oxaloacetate transaminase (SGOT), total bilirubin, Serum alkaline phosphatase (SALP) and also increases the elevated levels of superoxide dismutase (SOD) and catalase. The hepatoprotective activity was also supported by histopathological studies of liver tissue. Since results of biochemical studies of blood samples of carbon tetrachloride treated rats showed significant increase in the levels of serum enzyme activities and decreases in antioxidant parameters, reflecting the liver injury caused by CCl4 and blood samples from the animals treated with the ethanolic extract of Asparagus racemosus showed significant decrease in the levels of serum markers and increases the antioxidant parameters, indicating the protection of hepatic cells, the extract of above plant could afford significant protection against CCl4 induced Hepatocellular injury.
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